Cheltenham Royal Well Bus station is well served by National Express services to London Victoria, Bristol, Birmingham, Swindon, Cardiff, Plymouth, Manchester, Edinburgh and Glasgow. The bus station is located in the centre of the town.

There is also a Megabus service to London, offering a fast and affordable service to the capital. A range of bus companies are running services to local destinations like Oxford, Swindon, Cirencester, Stroud, Moreton-in-Marsh, Evesham etc.